反应详情

A mixture of 3-trifluoromethylbenzyl bromide (5.74 g, 24.0 mmol) and triethyl phosphite (4.98 g, 30 mmol) was heated at reflux under nitrogen for 3 hours. The excess triethyl phosphite was removed by distillation and the crude product obtained was distilled at 140°-145° C. at 4 mm to yield 6.44 g (90.7%) of analytically pure product as a clear liquid, D.C.I.M.S.[MH+, 297].

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 3 hours
3. customThe excess triethyl phosphite was removed by distillation
4. customthe crude product obtained
5. distillationwas distilled at 140°-145° C. at 4 mm
6. customto yield 6.44 g (90.7%) of analytically pure product as a clear liquid, D.C.I.M.S.[MH+, 297]