反应详情

A mixture of 4-trifluoromethylbenzyl bromide (5.68 g, 23.8 mmol) and triethyl phosphite(10.4 g, 63 mmol) was heated at reflux under nitrogen for 5 hours. The excess triethyl phosphite was removed by distillation and the crude product was purified by distillation at 95° C. (0.07 mm Hg.) to give 6.27 g, 89% of the product as an oil. D.C.I.M.S.[MH+,297].

1. temperaturewas heated
2. temperatureat reflux under nitrogen for 5 hours
3. customThe excess triethyl phosphite was removed by distillation
4. distillationthe crude product was purified by distillation at 95° C. (0.07 mm Hg.)