Ammonia → HCID 10036464, compound

HRID 1463591Notes

Reaction equation

HRID 1463591 reaction equation
[C:1]([CH2:3][CH2:4][P:5]([C:11]([CH3:14])([CH3:13])[CH3:12])(=[O:10])[O:6][CH:7]([CH3:9])[CH3:8])#[N:2].N>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([C:11]([CH3:13])([CH3:12])[CH3:14])(=[O:10])[O:6][CH:7]([CH3:8])[CH3:9]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 10420903HCID 10420903, compound

Product 1

HCID 10036464HCID 10036464, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 11.0 g of isopropyl 2-cyanoethyl(t-butyl)phosphinate, 17.0 g of ammonia and 1.7 g of Raney-Nickel in 110 ml of ethanol is hydrogenated during 5 hours. The catalyst is filtered off and the solvent removed by evaporation. The crude oil is purified by Kugelrohr-distillation to yield isopropyl 3-aminopropyl(t-butyl)phosphinate as an oil, b.p. 155°/1 Pa, nD20 =1.4600.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent removed by evaporation
  3. distillationThe crude oil is purified by Kugelrohr-distillation

Sources & evidence

ORD record
ord-8d3202b2263e455791b947bc2a93e5e3
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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