HCID 19090881, compound → HCID 9920471, compound

Participants

Reaction Steps

7.0 g of isopropyl 3-aminopropyl(n-propyl)phosphinate and 40 ml of 20% hydrochloric acid are stirred at reflux temperature overnight. The reaction mixture is evaporated to dryness, taken up in methanol and treated with propylene oxide. The white solid is filtered off and dried over phosphorous pentoxide to yield 3-aminopropyl(n-propyl)phosphinic acid×0.1 H2O as white crystals, m.p. 210°-213° .

Provenance & Evidence