HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Isopropyl 3-aminopropyl(ethyl)phosphinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Isopropyl 2-cyanoethyl(ethyl)phosphinate | HCID 19090919 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Isopropyl 3-aminopropyl(ethyl)phosphinate | HCID 19090904 | — |
Reaction Steps
To 34.1 g of isopropyl 2-cyanoethyl(ethyl)phosphinate in 500 ml of isopropanol are added 60 ml of liquid ammonia and 6.8 g of Raney-Nickel. The mixture is heated to 80° and treated with hydrogen at 100 bar. After 11/2 hours hydrogen-uptake stops. The reaction mixture is filtered and the filtrate distilled to give isopropyl 3-aminopropyl(ethyl)phosphinate as a colorless oil, b.p. 75°/13 Pa.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05300679 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-d31ee94fbad84602802c0581b775044d |
| Source note | uspto-grants-1994_04 |