HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Ethyl 3-aminopropyl(phenyl)phosphinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 2-cyanoethyl(phenyl)phosphinate | HCID 19090907 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 3-aminopropyl(phenyl)phosphinate | HCID 19090874 | — |
Reaction Steps
To 22.72 g of ethyl 2-cyanoethyl(phenyl)phosphinate in 400 ml of ethanol are added 34 g of liquid ammonia and 4.5 g of Raney-Nickel. The mixture is heated to 80° and treated with hydrogen at 100 bar. After 30 minutes hydrogen up-take stops. The reaction mixture is filtered and the filtrate distilled to give ethyl 3-aminopropyl(phenyl)phosphinate as a colorless oil, b.p. 110°/13 Pa.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05300679 |
| Source dataset | uspto-grants-1994_04 |
| ORD ID | ord-ac6d47e7a8a04d329856ced0564e5b63 |
| Source note | uspto-grants-1994_04 |