Ammonia → HCID 19090926, compound

HRID 1463610Notes

Reaction equation

HRID 1463610 reaction equation
[C:1]([CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8])#[N:2].N>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][P:5]([CH:10]([O:15][CH2:16][CH2:17][CH3:18])[O:11][CH2:12][CH2:13][CH3:14])(=[O:9])[O:6][CH2:7][CH3:8]

Participants

5

Reactant 2

HCID 222AmmoniaHCID 19090879HCID 19090879, compound

Product 1

HCID 19090926HCID 19090926, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4,35 g of ethyl 2-cyanoethyl(di-n-propyloxymethyl)phosphinate, 10 g of ammonia and 2.3 g of Raney-Nickel in 170 ml of ethanol is hydrogenated for 10.5 hours. The catalyst is filtered off and the solvent is removed by evaporation. The crude oil is purified by distillation to yield ethyl 3-aminopropyl(di-n-propyloxymethyl)phosphinate as a colourless oil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is removed by evaporation
  3. distillationThe crude oil is purified by distillation

Sources & evidence

ORD record
ord-67129471cb684b0cbf0da89953064071
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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