Ethanol → HCID 53872425, compound

HRID 1463614Notes

Reaction equation

HRID 1463614 reaction equation
C(OC([P:9]([CH:14]1[CH2:18][CH2:17][CH2:16][O:15]1)(=[O:13])[O:10][CH2:11][CH3:12])(OCC)C)C.C(O)C.C[Si](Cl)(C)C>ClCCl>[CH2:11]([O:10][P:9]([CH:14]1[CH2:18][CH2:17][CH2:16][O:15]1)[OH:13])[CH3:12]

Participants

5

Reactant 3

HCID 702EthanolHCID 6397ChlorotrimethylsilaneHCID 19090911HCID 19090911, compound

Product 1

HCID 53872425HCID 53872425, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 1 g of ethyl 1,1-diethoxyethyl(tetrahydrofuran-2-yl)phosphinate in 10 ml of dichloromethane containing 1% (b.v.) of ethanol is treated with 0.71 g of trimethylsilylchloride. The faintly cloudy solution is stirred overnight at room temperature after which time thin layer chromatography indicates complete reaction. Removal of the solvent in vacuo affords a colourless oil which after distillation yields P-tetrahydrofuran-2-yl-phosphonous acid ethyl ester, b.p. 90°/8×10-2 mbar.

Workup

  1. customreaction
  2. customRemoval of the solvent in vacuo
  3. customaffords a colourless oil which
  4. distillationafter distillation

Sources & evidence

ORD record
ord-82e0b69558ad401087cbcf391f29086b
Source dataset
uspto-grants-1994_04
Patent number
US05300679

Reaction notes

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