2-Bromo-9H-fluorene → HCID 19922464, compound

Participants

Reaction Steps

The title compound was prepared following the procedure of Example 5 from 1.0 g (4.08 mmole) of 2-bromofluorene, 1.5 g of 4-picolylchloride hydrochloride, 100 mg of cetyl tri-n-butyl phosphonium bromide, 20 ml of 50% sodium hydroxide solution, and 20 ml toluene by reaction at 50° for 1 hr. The product was chromatographed (silica, CH2Cl2 /CH3OH, 100:1), m.p. (dihydrochloride) >300° NMR (200 MHz,CDCL3) δ: 3.39(dd,4H), 6.48(d,4H), 7.10-7.67 (m,7H-arom.), 8.12(d,J=5.7 Hz,4H). HRMS calculated for C25H19BrN2 : 426.0758 Found: 426.0758

Provenance & Evidence