4-Azafluorene → HCID 10545749, compound

Participants

Reaction Steps

Following the procedure described in Example 608, Part D, alkylation of 2.1 g (12.6 mole) of 4-azafluorene, in the presence of 1.51 g (31.45 mmole) of 50% sodium hydride with 5.0 g (30.4 mmole) of 4-picolyl-chloride yielded 2.8 g. Flash chromatography with ethyl acetate yielded 2.0 g of material containing a small amount of color. Recrystallization from butyl chloride yielded 1.5 g of pure compound, m.p. 163°-4°.

Provenance & Evidence