Sodium Hydroxide → 2-Methyl-2-(prop-2-yn-1-yl)propanedioic acid

Participants

Reaction Conditions

Reaction Steps

23.7 g [53] (127 mmol) were dissolved in 200 ml methanol and a solution of 28.3 g (708 mmol) of NaOH in 50 ml water was slowly added dropwise. The mixture was heated to 50° C. in a water bath for two hours, the solvent was removed in a rotary evaporator and the residue was dissolved in water. The mixture was acidified with semi-concentrated hydrochloric acid and the free carboxcylic acid was exacted with chloroform, washed and dried.

Provenance & Evidence