HCID 15285849, compound → HCID 15285850, compound

HRID 1463793Notes

Reaction equation

HRID 1463793 reaction equation
Br[C:2]1[C:3]([CH2:14][P:15]([OH:18])([OH:17])=[O:16])=[N:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=2)[CH:7]=1>[Pd].O>[P:15]([CH2:14][C:3]1[CH:2]=[CH:7][N:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[N:10]=[C:5]2[N:4]=1)([OH:17])([OH:18])=[O:16]

Participants

4

Reactant 1

HCID 15285849HCID 15285849, compound

Product 1

HCID 15285850HCID 15285850, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

6-Bromo-7-phosphonomethyl-imidazo[1,2-a]pyrimidine-2-carboxylic acid 18 (15 mg) was introduced in a 250 mL Parr bottle with 0.5N NAOH (1 mL), water (15 mL) and Pd on Carbon (5%, 20 mg). The bottle was evacuated, filled with hydrogen and shaken for one hour at room temperature. The product was purified by passing through a strongly basic ion-exchange column. The product 19 was eluted with 1N HCl.

Workup

  1. customThe bottle was evacuated
  2. additionfilled with hydrogen
  3. customThe product was purified
  4. washThe product 19 was eluted with 1N HCl

Sources & evidence

ORD record
ord-9ccaac26808f4884bae7512e3be5680c
Source dataset
uspto-grants-1994_04
Patent number
US05302586

Reaction notes

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