Morpholine → HCID 131718380, compound

HRID 1463794Notes

Reaction equation

HRID 1463794 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:14]=[CH:13][CH:12]=[C:6]2[C:7]([NH:9][C:10](=[O:11])[C:5]=12)=[O:8].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1>C(OCC)C>[N:15]1([CH2:2][CH2:3][C:4]2[CH:14]=[CH:13][CH:12]=[C:6]3[C:7]([NH:9][C:10](=[O:11])[C:5]=23)=[O:8])[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 219600212-Bromoethylphthalimide

Product 1

HCID 131718380HCID 131718380, compoundYield 52.1%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-Bromoethylphthalimide (508 mg; 2.0 mmoles) and morpholine (0.35 ml; 4.0 mmoles) were dissolved in anhydrous ethyl ether (5 ml). The mixture was allowed to stir at room temperature for 30 hours approx. The reaction was discontinued by solvent evaporation under reduced pressure. The obtained residue was purified by chromatography on silica gel (CH2Cl2 /MeOH 95:5) yielding 271 mg of pure product.

Workup

  1. customThe reaction was discontinued by solvent evaporation under reduced pressure
  2. customThe obtained residue was purified by chromatography on silica gel (CH2Cl2 /MeOH 95:5)

Sources & evidence

ORD record
ord-af0b219cc03e4cd8a64a41774bf7a047
Source dataset
uspto-grants-1994_04
Patent number
US05302593

Reaction notes

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