Sodium hydride → HCID 136378387, compound

Participants

Reaction Conditions

Reaction Steps

0.85 g of a 55% sodium hydride dispersion in mineral oil is added in portions to a solution of 2.7 g of 2-nitroimino-imidazolidine in 70 ml of acetonitrile. The mixture is stirred for 1.5 hours under a nitrogen atmosphere, and then 3.72 g of 2-chloro-5-chloromethyl-pyridine-N-oxide are added in portions. The reaction mixture is stirred at room temperature for 16 hours and then filtered. The crude product is crystallised out by cooling the filtrate to 0° C. The product is separated off and washed with diethyl ether, yielding pure 2-chloro-5-(2-nitroimino-imidazolidin-1-yl-methyl)-pyridine-N-oxide, m.p. 200° C. (with decomposition).

Provenance & Evidence