Chloride → HCID 54355284, compound

Participants

Reaction Steps

2-Ethylexanoyl chloride (0.43 g) was added to a solution of potassium thiocyanate (0.506 g) in dioxane (10 ml), followed by stirring at 55° to 60° C. for 4 hours. Then, 2-amino-4-(5,6,7,8-tetrahydro-2-naphthyl)thiazole (0.5 g) was added to the solution, which was stirred at 55° to 60° C. for 3 hours. The reaction mixture was poured into water, and the crystals which separated out were recovered by filtration, washed with water and isopropyl ether, successively, and recrystallized from dichloromethane-isopropyl ether to give 1-(2-ethylhexanoyl) 3-[4-(5,6,7,8-tetrahydro-2-naphthyl)-2-thiazolyl]thiourea (0.438 g, 58.1%) in the form of colorless needles. m.p. 178°-179° C.

Provenance & Evidence