Potassium Carbonate → HCID 19088498, 화합물

참여 물질

반응 단계

A mixture containing 2,2-diphenyl-5-methylaminopentanamide (0.3 g--see Preparation 3), 5-(2-bromoethyl)indane (0.24 g--see Preparation 6), anhydrous potassium carbonate (0.5 g) and acetonitrile (10 ml) was heated under reflux for 16 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml), the layers separated and the aqueous layer extracted with dichloromethane (2×20 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give an oil which was purified by column chromotography on silica eluting with dichloromethane containing methanol (0% up to 6%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as a foam, yield 0.23 g.

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