Potassium Carbonate → HCID 19088514, compound

Participants

Reaction Steps

A mixture containing 2,2-diphenyl-5-methylaminopentanamide (0.3 g--see Preparation 3), 3-methylphenethyl bromide (0.21 g), anhydrous potassium carbonate (0.5 g) and acetonitrile (20 ml) was heated under reflux for 8 hours. The mixture was partitioned between dichloromethane (30 ml) and 10% aqueous sodium carbonate (30 ml), the layers separated and the aqueous layer extracted with dichloromethane (2×20 ml). The combined dichloromethane extracts were dried (MgSO4) and concentrated in vacuo to give an oil which was purified by column chromatography on silica eluting with dichloromethane containing methanol (5%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as an oil, yield 0.23 g.

Provenance & Evidence