2-Vinylpyridine → HCID 19088490, compound

Participants

Reaction Steps

A solution containing 2,2-diphenyl-5-methylaminopentanamide (2.0 g--see Preparation 3) and 2-vinylpyridin (1.1 ml) in dioxan (15 ml) was heated under reflux for 48 hours. The mixture was concentrated in vacuo and the residue partitioned between dichloromethane (50 ml) and water (50 ml). The dichloromethane layer was dried (MgSO4) and concentrated in vacuo to give a solid which was purified by column chromatography eluting with hexane containing dichloromethane (50% up to 100%) and then with dichloromethane containing methanol (0% up to 5%). The product-containing fractions were combined and concentrated in vacuo to give the title compound as an oil which was crystallised from acetonitrile, yield 0.5 g, m.p. 134°-136°.

Provenance & Evidence