Propanal → 4-(3-Benzyloxy-5-fluorophenyl)-2,4-diethyl-1,3-dioxolane

Participants

Reaction Steps

Using the procedures described in the last two paragraphs of the portion of Example 1 which is concerned with the preparation of starting materials, 2-(3-benzyloxy-5-fluorophenyl)butane-1,2-diol (1.02 g) was reacted with propionaldehyde (6 ml) in the presence of concentrated sulphuric acid (1 drop) to give 4-(3-benzyloxy-5-fluorophenyl)-2,4-diethyl-1,3-dioxolane, as an oil and as a mixture of diastereoisomers, and this product was hydrogenolysed to give the required starting material (0.5 g, 60%), as an oil.

Provenance & Evidence