Dimethyl Sulfoxide → HCID 57320502, compound

Participants

Reaction Steps

The tosylate (2) was dissolved in dimethyl sulfoxide and sodium cyanide (3.92 g) was added thereto, and the resultant mixture was stirred at 60° to 70° C. for 2 hours The reaction mixture was worked up with the conventional procedure to give the crude cyano compound (3). The crude cyano compound (3) was dissolved in methanol, and potassium carbonate (2.76 g) was added thereto, and the resultant mixture was stirred for 15 hours. The reaction mixture was concentrated under reduced pressure, and the obtained residue was chromatographed on a silicagel column to give the titled compound (4).

Provenance & Evidence