Tetrabutylammonium Fluoride → HCID 86746995, compound

Participants

Reaction Steps

To a solution of methyl (Z)-7-[(1 R)-(2 R,3 R,5 S)-2-{4 (RS)-t-butyldimethylsiloxy-5,5-difluorooctyl}-5-hydroxy-3-tetrahydropyranyloxycyclopentyl]hept-5-enoate (17) (1.90 g) in tetrahydrofuran was added tetrabutylammonium fluoride in tetrahydrofuran (1.0M, 15.7 ml). The resultant mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure and the obtained residue was subjected to silicagel column chromatography to give the titled compound (18).

Provenance & Evidence