2-(4-Methoxyphenyl)propan-2-amine → N-[1-(4-Methoxyphenyl)-1-methylethyl]-4-methyl-3-oxo-4-azaandrost-5-ene-17-carboxamide

HRID 1463949Notes

Reaction equation

HRID 1463949 reaction equation
[CH3:1][N:2]1[C:19](=[O:20])[CH2:18][CH2:17][C@@:16]2([CH3:21])[C:3]1=[CH:4][CH2:5][C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C@@H:10]2[C:22]([OH:24])=O.[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([NH2:36])([CH3:35])[CH3:34])=[CH:29][CH:28]=1>>[CH3:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]([NH:36][C:22]([CH:10]2[CH2:9][CH2:8][C@H:7]3[C@H:6]4[C@H:15]([CH2:14][CH2:13][C@:11]23[CH3:12])[C@:16]2([CH3:21])[C:3]([N:2]([CH3:1])[C:19](=[O:20])[CH2:18][CH2:17]2)=[CH:4][CH2:5]4)=[O:24])([CH3:34])[CH3:35])=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 110082782-(4-Methoxyphenyl)propan-2-amineHCID 228121504-Methyl-3-oxo-4-azaandrost-5-ene-17beta-carboxylic acid

Product 1

HCID 54523626N-[1-(4-Methoxyphenyl)-1-methylethyl]-4-methyl-3-oxo-4-azaandrost-5-ene-17-carboxamideYield 72%

Procedure

The title compound was prepared in a yield of 72% in a similar manner to that described in Example 37 by reacting 4-methyl-3-oxo-4-azaandrost-5-ene-17β-carboxylic acid (prepared as described in Preparation 5) and 1-(4-methoxyphenyl)-1-methylethylamine.

Sources & evidence

ORD record
ord-53ddde1cff6e4434b5ba20a1ef1ac8f1
Source dataset
uspto-grants-1994_04
Patent number
US05302621

Reaction notes

Loading…