3-Oxo-4-aza-5-androstene-17beta-carboxylic acid → HCID 67750873, compound

HRID 1463953Notes

Reaction equation

HRID 1463953 reaction equation
[O:1]=[C:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:21](O)=[O:22])[NH:3]1.[OH:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([NH2:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:27][CH:26]=1>>[OH:24][C:25]1[CH:26]=[CH:27][C:28]([CH:31]([NH:38][C:21]([C@H:11]2[CH2:10][CH2:9][C@H:8]3[C@H:7]4[C@H:16]([CH2:15][CH2:14][C@:12]23[CH3:13])[C@:17]2([CH3:20])[C:4]([NH:3][C:2](=[O:1])[CH2:19][CH2:18]2)=[CH:5][CH2:6]4)=[O:22])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 4754473-Oxo-4-aza-5-androstene-17beta-carboxylic acidHCID 49622034-[Amino(phenyl)methyl]phenol

Product 1

HCID 67750873HCID 67750873, compoundYield 77%

Procedure

The title compound was prepared in a yield of 77% in a similar manner to that described in Example 37 by reacting 3-oxo-4-azaandrost-5-ene-17β-carboxylic acid and α-(4-hydroxyphenyl)benzylamine.

Sources & evidence

ORD record
ord-0261966c826948fba39b2245aa712b6a
Source dataset
uspto-grants-1994_04
Patent number
US05302621

Reaction notes

Loading…