HRID1463953

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@]12CC[C@H]3[C@@H](CC=C4NC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)O

HCID475447

3-Oxo-4-aza-5-androstene-17beta-carboxylic acid

C19H27NO3

HCID4962203

4-[amino(phenyl)methyl]phenol

C13H13NO

PRODUCTS

生成物

结构：C[C@]12CC[C@H]3[C@@H](CC=C4NC(=O)CC[C@@]43C)[C@@H]1CC[C@@H]2C(=O)NC(c1ccccc1)c1ccc(O)cc1

HCID67750873

未命名化合物

收率 77%

PROCEDURE

实验过程

The title compound was prepared in a yield of 77% in a similar manner to that described in Example 37 by reacting 3-oxo-4-azaandrost-5-ene-17β-carboxylic acid and α-(4-hydroxyphenyl)benzylamine.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0261966c826948fba39b2245aa712b6a
来源数据集: uspto-grants-1994_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05302621
来源说明: uspto-grants-1994_04

反应 SMILES

[O:1]=[C:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:21](O)=[O:22])[NH:3]1.[OH:24][C:25]1[CH:30]=[CH:29][C:28]([CH:31]([NH2:38])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:27][CH:26]=1>>[OH:24][C:25]1[CH:26]=[CH:27][C:28]([CH:31]([NH:38][C:21]([C@H:11]2[CH2:10][CH2:9][C@H:8]3[C@H:7]4[C@H:16]([CH2:15][CH2:14][C@:12]23[CH3:13])[C@:17]2([CH3:20])[C:4]([NH:3][C:2](=[O:1])[CH2:19][CH2:18]2)=[CH:5][CH2:6]4)=[O:22])[C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:29][CH:30]=1