Floxuridine → HCID 22851266, compound

Participants

Reaction Steps

To a solution of the active drug, preferably 2'-deoxy-5-fluorouridine, an N-protected amino acid, preferably N-acetyl-D-valine, and triphenylphosphine in an anhydrous polar aprotic solvent is added diisopropylazodicarboxylate. Upon completion of the reaction, the mixture is concentrated under reduced pressure. The prodrug, preferably a compound of Formula 11, most preferably, 2'-deoxy-5'-O-(N-acetyl-D-valinyl)-5-fluorouridine, may be isolated by conventional means.

Provenance & Evidence