Acetic Anhydride → HCID 19089093, compound

HRID 1463985Notes

Reaction equation

HRID 1463985 reaction equation
C(O[C:5](=[O:7])C)(=O)C.[CH3:8][C:9]1[N:13]2[N:14]=[CH:15][CH:16]=[C:12]2[NH:11][CH:10]=1>C(O)=O>[CH:5]([N:11]1[C:12]2[N:13]([N:14]=[CH:15][CH:16]=2)[C:9]([CH3:8])=[CH:10]1)=[O:7]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178430816HCID 178430816, compound

Product 1

HCID 19089093HCID 19089093, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of acetic anhydride (4.83 ml) and formic acid (3.86 ml) was stirred at room temperature for 1 hour. The solution was cooled at ice-bath and 3-methyl-1H-imidazo[1,2-b]pyrazole (3.1 g) was added thereto. The mixture was stirred at the same condition for 1 hour. The reaction mixture was evaporated and the residue was subjected to column chromatography on silica gel using ethyl acetate as an eluent. Fractions containing the object compound were combined and the solvent was evaporated to give 1-formyl-3-methyl-1H-imidazo[1,2-b]pyrazole (2.99 g).

Workup

  1. temperatureThe solution was cooled at ice-bath
  2. stirringThe mixture was stirred at the same condition for 1 hour
  3. customThe reaction mixture was evaporated
  4. additionFractions containing the object compound
  5. customthe solvent was evaporated

Sources & evidence

ORD record
ord-1016041e603f474c837c229e5f171a08
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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