Acetic Anhydride → HCID 19089107, compound

HRID 1463989Notes

Reaction equation

HRID 1463989 reaction equation
C(O[C:5](=[O:7])C)(=O)C.[NH2:8][CH2:9][CH2:10][N:11]1[C:18]2[N:14]([N:15]=[CH:16][CH:17]=2)[CH:13]=[CH:12]1>C(O)=O>[CH:5]([NH:8][CH2:9][CH2:10][N:11]1[C:18]2[N:14]([N:15]=[CH:16][CH:17]=2)[CH:13]=[CH:12]1)=[O:7]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19089091HCID 19089091, compound

Product 1

HCID 19089107HCID 19089107, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A mixture of acetic anhydride (19.5 ml) and formic acid (15.7 ml) was stirred at room temperature for 45 minutes. The mixture was cooled at 5° C. and 1-(2-aminoethyl)-1H-imidazo[1,2-b]pyrazole was added thereto. The mixture was stirred for 1 hour under ice-cooling. The reaction mixture was evaporated and the residue was subjected to column chromatography on silica gel using a mixture of ethyl acetate and methanol (9:1) as eluent. Fractions containing the object compound were combined and evaporated to give 1-(2-formylaminoethyl)-1H-imidazo[1,2-b]pyrazole (7 g).

Workup

  1. temperatureThe mixture was cooled at 5° C.
  2. stirringThe mixture was stirred for 1 hour under ice-
  3. temperaturecooling
  4. customThe reaction mixture was evaporated
  5. additiona mixture of ethyl acetate and methanol (9:1) as eluent
  6. additionFractions containing the object compound
  7. customevaporated

Sources & evidence

ORD record
ord-b190b82a851f486697bc73a6c53214c8
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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