Dimethylamine → HCID 19089099, compound

HRID 1463990Notes

Reaction equation

HRID 1463990 reaction equation
C(O[C:4]([CH2:6][N:7]1[C:14]2[N:10]([N:11]=[CH:12][CH:13]=2)[CH:9]=[CH:8]1)=[O:5])C.[CH3:15][NH:16][CH3:17]>C(O)C>[CH3:15][N:16]([CH3:17])[C:4]([CH2:6][N:7]1[C:14]2[N:10]([N:11]=[CH:12][CH:13]=2)[CH:9]=[CH:8]1)=[O:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19089097HCID 19089097, compound

Product 1

HCID 19089099HCID 19089099, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-ethoxycarbonylmethyl-1H-imidazo-[1,2-b]pyrazole (7.0 g) in ethanol (35 ml) was added 50% dimethylamine aqueous solution (17 ml). The mixture was stirred at room temperature for 5 hours. The reaction mixture was evaporated in vacuo. The resultant crude powder was subjected to column chromatography on silica gel using a mixture of ethyl acetate and methanol as an eluent. Fractions containing the object compound were combined and evaporated in vacuo. The resultant precipitate was collected and washed with diisopropyl ether to give 1-(N,N-dimethylcarbamoylmethyl)-1H-imidazo[1,2-b]-pyrazole (1.6 g).

Workup

  1. customThe reaction mixture was evaporated in vacuo
  2. additiona mixture of ethyl acetate and methanol as an eluent
  3. additionFractions containing the object compound
  4. customevaporated in vacuo
  5. customThe resultant precipitate was collected
  6. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-75904b96d5f54cbd9febfbf8faf90747
Source dataset
uspto-grants-1994_04
Patent number
US05302712

Reaction notes

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