Boron tribromide → HCID 67852482, compound

Participants

Reaction Steps

A solution of 147 mg (0.47 mmol) of Compound Q from Step F above in 10 mL methylene chloride at -78° C. was treated with 90 mL boron tribromide, and the mixture was stirred for 4 hours while coming to room temperature. The reaction was quenched with 10 mL dry methanol and stirred for 10 minutes. The solvent was evaporated under reduced pressure, and the residue was treated with a second 10 mL portion of methanol. After 10 minutes, the solvent was evaporated at 10 mm Hg and 50° C. for 45 minutes to give 180 mg (100%) of the crude hydrobromide, 200 MHz NMR(d6-DMSO) d 2.97(s,3H), 2.90-3.90(m,7H),5.02(d,1H,J=8 Hz),6.99(s,1H),7.36(m,5H).

Provenance & Evidence