Dimethylcyanamide → HCID 178484370, compound

HRID 1464040Notes

Reaction equation

HRID 1464040 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:15][N:16]([CH3:19])[C:17]#[N:18].[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24]>C1C(O)=CC=CC=1C.CO>[C:20]([OH:27])(=[O:26])/[CH:21]=[CH:22]/[C:23]([OH:25])=[O:24].[C:4]1([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[NH:2][C:17]([N:16]([CH3:19])[CH3:15])=[NH:18]

Participants

6

Reactant 3

HCID 15112DimethylcyanamideHCID 444972Fumaric AcidHCID 52843472-Biphenylamine hydrochloride

Product 1

HCID 178484370HCID 178484370, compound

Reagents, catalysts & solvents 2

HCID 342M-CresolSolventHCID 887MethanolSolvent

Procedure

A mixture of 2-aminobiphenyl hydrochloride (9.2 g) and N,N-dimethylcyanamide (4.8 g) in m-cresol (30 ml) was heated at 90°-95° C. for 10 hours to yield an oil which was dissolved in methanol (60 ml) and treated with fumaric acid (4.5 g) to give N-(2-biphenylyl)-N',N'-dimethylguanidine fumarate (m.p. 175°-176° C.) which was recrystallised from a 2:3 mixture of methanol and ether.

Workup

  1. temperaturewas heated at 90°-95° C. for 10 hours
  2. customto yield an oil which

Sources & evidence

ORD record
ord-eb626da62ca94340a7419519f5c3b18a
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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