4-Morpholinecarbonitrile → HCID 178511978、化合物

関与物質

反応手順

A mixture of 2-aminobiphenyl hydrochloride (6.17 g) and 4-cyanomorpholine (5.05 g) in m-cresol (25 ml) was heated at 90°-95° C. for 15 hours to yield N-(2-biphenylyl)-4-morpholine carboxamidine (m.p. 153°-154° C.) which was recrystallised from ethylacetate. N-(2-Biphenylyl)morpholine-4-carboxamidine (3.5 g) was dissolved in methanol (15 ml) and treated with fumaric acid (1.45 g) to give N-(2-biphenylyl)morpholine-4-carboxamidine fumarate (m.p. 222°-223° C.) which was recrystallised from a 1:1 mixture of methanol and ether.

情報源と証拠