4-Morpholinecarbonitrile → HCID 178488541, compound

Participants

Reaction Steps

A mixture of 2-amino-4-methoxybiphenyl hydrochloride (4.4 g) and 4-cyanomorpholine (3.14 g) in m-cresol (25 ml) was heated at 90°-95° C. for 20 hours to yield N-(4-methoxy-2-biphenylyl)morpholine-4-carboxamidine (m.p. 140°-142° C.) which was recrystallised from ethylacetate. N-(4-Methoxy-2-biphenylyl)morpholine-4-carboxamidine (1.2 g) was dissolved in methanol (10 ml) and treated with fumaric acid (1.45 g) to give N-(4-methoxy-2-biphenylyl)morpholine-4-carboxamidine fumarate [m.p. 120° (dec)] which was recrystallised from a 1:1 mixture of methanol and ether.

Provenance & Evidence