Dimethylcyanamide → HCID 178492311, compound

HRID 1464050Notes

Reaction equation

HRID 1464050 reaction equation
[ClH:1].[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH3:17][N:18]([CH3:21])[C:19]#[N:20]>C1C(O)=CC=CC=1C>[ClH:1].[CH3:10][O:9][C:6]1[CH:7]=[CH:8][C:3]([NH:2][C:19]([N:18]([CH3:21])[CH3:17])=[NH:20])=[C:4]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:5]=1

Participants

4

Reactant 2

HCID 15112DimethylcyanamideHCID 190892652-Amino-5-methoxybiphenyl hydrochloride

Product 1

HCID 178492311HCID 178492311, compound

Reagents, catalysts & solvents 1

HCID 342M-CresolSolvent

Procedure

2-Amino-5-methoxybiphenyl hydrochloride (0.4 g) was heated with N,N-dimethylcyanamide (0.3 ml) in m-cresol (0.5 ml) at 110° C. for 8 hours to give a residue which was triturated with ether and crystallised from a 1:1 mixture of acetone and ether to give N-(5-methoxy-2-biphenylyl)-N',N'-dimethyl guanidine hydrochloride (m.p. 160° C.).

Workup

  1. customto give a residue which
  2. customwas triturated with ether
  3. customcrystallised from a 1:1 mixture of acetone and ether

Sources & evidence

ORD record
ord-8b48d5c7a4e944709905cd4bae766cbe
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

Loading…