Dimethylcyanamide → HCID 178503256, compound

HRID 1464051Notes

Reaction equation

HRID 1464051 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH3:10])=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH3:17][N:18]([CH3:21])[C:19]#[N:20].[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]/[C:25]([OH:27])=[O:26]>C1C(O)=CC=CC=1C.CO>[C:22]([OH:29])(=[O:28])/[CH:23]=[CH:24]/[C:25]([OH:27])=[O:26].[CH3:17][N:18]([CH3:21])[C:19]([NH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH3:10])=[CH:5][C:4]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[NH:20].[CH3:17][N:18]([CH3:21])[C:19]([NH:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][CH3:10])=[CH:5][C:4]=1[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)=[NH:20]

Participants

6

Reactant 3

HCID 15112DimethylcyanamideHCID 444972Fumaric AcidHCID 19089181HCID 19089181, compound

Product 1

HCID 178503256HCID 178503256, compound

Reagents, catalysts & solvents 2

HCID 342M-CresolSolventHCID 887MethanolSolvent2×

Procedure

Reaction of 2-amino-5-methylthiobiphenyl hydrochloride (1.6 g) with N,N-dimethylcyanamide (0.83 g) in m-cresol (1 ml) at 80° C. for 6 hours yielded a colourless solid which was dissolved in methanol (50 ml) and treated with a solution of fumaric acid (0.61 g) in methanol (50 ml) to give N,N-dimethyl-N'-(5-methylthio-2-biphenylyl)guanidine hemifumarate as a colourless solid (m.p. 207° C.).

Workup

  1. customyielded a colourless solid which

Sources & evidence

ORD record
ord-83419c29bc2042c69b87b69bd53fb44d
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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