M-Cresol → HCID 178425554, compound

HRID 1464055Notes

Reaction equation

HRID 1464055 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[CH3:16][N:17]([CH3:20])[C:18]#[N:19].C1C(O)=CC=CC=1C>>[CH3:16][N:17]([CH3:20])[C:18]([NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)=[NH:19]

Participants

4

Reactant 3

HCID 342M-CresolHCID 15112DimethylcyanamideHCID 190892122-Amino-6-methylbiphenyl hydrochloride

Product 1

HCID 178425554HCID 178425554, compound

Procedure

A mixture of 2-amino-6-methylbiphenyl hydrochloride (2.98 g), N,N-dimethylcyanamide (1.46 g) and m-cresol (25 ml) was heated at 90°-95° C. for 6 hours to give N,N-dimethyl-N'-(6-methyl-2-biphenylyl)guanidine (m.p. 181°-182° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 90°-95° C. for 6 hours

Sources & evidence

ORD record
ord-732eacad3f0b463ebd4525b6a80997cf
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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