M-Cresol → N,N-dimethyl-N'-(4'-methyl-2-biphenylyl)guanidine

HRID 1464059Notes

Reaction equation

HRID 1464059 reaction equation
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=1.[CH3:16][N:17]([CH3:20])[C:18]#[N:19].C1C(O)=CC=CC=1C>>[CH3:16][N:17]([CH3:20])[C:18]([NH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[CH:11][C:12]([CH3:15])=[CH:13][CH:14]=1)=[NH:19]

Participants

4

Reactant 3

HCID 342M-CresolHCID 15112DimethylcyanamideHCID 27598182-Amino-4'-methylbiphenyl hydrochloride

Product 1

HCID 178423720N,N-dimethyl-N'-(4'-methyl-2-biphenylyl)guanidine

Procedure

A mixture of 2-amino-4'-methylbiphenyl hydrochloride (5.3 g), N,N-dimethylcyanamide (2.55 g) and m-cresol (25 ml) was heated at 90°-95° C. for 10 hours to give N,N-dimethyl-N'-(4'-methyl-2-biphenylyl)guanidine (m.p. 147°-148° C.) which was recrystallised from hexane.

Workup

  1. temperaturewas heated at 90°-95° C. for 10 hours

Sources & evidence

ORD record
ord-2e7424f79cfe4d7a8cc261b8cb3dd7e6
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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