Potassium Hydroxide → 2-Biphenylylcyanamide

HRID 1464070Notes

Reaction equation

HRID 1464070 reaction equation
[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([NH2:10])=S.[OH-].[K+]>O.O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>[C:1]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]#[N:10]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 1471602N-(1,1'-Biphenyl)-2-ylthiourea

Product 1

HCID 190892212-Biphenylylcyanamide

Reagents, catalysts & solvents 2

HCID 962WaterSolvent3×HCID 22456Lead diacetate trihydrateSolvent

Procedure

A suspension of N-(2-biphenylyl)thiourea (7.8 g) in water (60 ml) was reacted with a solution of potassium hydroxide (19.15 g) in water (60 ml), lead acetate trihydrate (12.96) in water (60 ml) was added and the reaction mixture heated at 90°-95° C. for 30 minutes and filtered. The filtrate was acidified with acetic acid with cooling to yield 2-biphenylylcyanamide as a colourless solid (m.p. 85°-87° C.).

Workup

  1. additionwas added
  2. temperaturethe reaction mixture heated at 90°-95° C. for 30 minutes
  3. filtrationfiltered
  4. temperaturewith cooling

Sources & evidence

ORD record
ord-6edbe5a8773c4253a5847c5b311995d2
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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