Potassium Hydroxide → 5-Methyl-2-biphenylylcyanamide

HRID 1464081Notes

Reaction equation

HRID 1464081 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]([NH2:17])=S)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH:14][C:15]#[N:17])=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 19089313N-(5-methyl-2-biphenylyl)thiourea

Product 1

HCID 190891925-Methyl-2-biphenylylcyanamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A suspension of N-(5-methyl-2-biphenylyl)thiourea (6.5 g) in water (50 ml) was reacted with a solution of potassium hydroxide (15 g) in water (50 ml). Lead acetate trihydrate (10.2 g) in water (50 ml) was added and the mixture heated at 90°-95° C. for 1 hour to give 5-methyl-2-biphenylylcyanamide as a colourless solid (m.p. 80° C.).

Workup

  1. temperaturethe mixture heated at 90°-95° C. for 1 hour

Sources & evidence

ORD record
ord-3e000a7304f44f14adbf0d4c0a4fe5e2
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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