1-(Methylsulfonyl)piperazine → HCID 178504962, compound

HRID 1464089Notes

Reaction equation

HRID 1464089 reaction equation
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]#[N:9].[CH3:16][S:17]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(=[O:19])=[O:18]>C(O)C>[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8]([N:23]1[CH2:24][CH2:25][N:20]([S:17]([CH3:16])(=[O:19])=[O:18])[CH2:21][CH2:22]1)=[NH:9]

Participants

4

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 190892212-Biphenylylcyanamide

Product 1

HCID 178504962HCID 178504962, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 2-biphenylylcyanamide (3.8 g), 1-methanesulphonylpiperazine (3.8 g) and ethanol (60 ml) was heated at 90°-95° C. for 12 hours to give N-(2-biphenylyl)-4-methanesulphonylpiperazine-1-carboxamidine (m.p. 178°-180° C.) which was recrystallized from ethanol.

Workup

  1. temperaturewas heated at 90°-95° C. for 12 hours

Sources & evidence

ORD record
ord-469d7af6198a41bc95d01527a2a0b321
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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