Potassium Hydroxide → 4'-Chloro-2-biphenylylcyanamide

HRID 1464098Notes

Reaction equation

HRID 1464098 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]([NH2:17])=S)=[CH:4][CH:3]=1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[NH:14][C:15]#[N:17])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 15175541N-(4'-chloro-2-biphenylyl)thiourea

Product 1

HCID 190892434'-Chloro-2-biphenylylcyanamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Procedure

A suspension of N-(4'-chloro-2-biphenylyl)thiourea (7.1 g) in water (60 ml) was reacted with potassium hydroxide (15.1 g) in water (60 ml). Lead acetate trihydrate (10.3 g) in water (60 ml) was added and the mixture heated at 90°-95° C. for 1 hour to give 4'-chloro-2-biphenylylcyanamide (m.p. 106°-107° C.).

Workup

  1. temperaturethe mixture heated at 90°-95° C. for 1 hour

Sources & evidence

ORD record
ord-c69afb2dcdfd40f89c8beba727729543
Source dataset
uspto-grants-1994_04
Patent number
US05302720

Reaction notes

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