Hydrochloric Acid → HCID 15062348, compound

Participants

Reaction Steps

Ethyl 2-(4-[perfluorohexyl]phenyl)propionate (100 mg, 0.20 mmol) was dissolved in 5 mL of ethanol and 5 mL of 1N NaOH. The solution was heated to reflux for 1 hour, cooled to room temperature, poured into 30 mL of 1N HCl and extracted with three 10-mL portions of dicholormethane. Combination, drying (MgSO4), and concentration of the organic layers gave a residue which was purified by PTLC (one 2 mm silica gel plate eluted with 15% methanol-85% dichloromethane) to give 54 mg (57% yield) of 2-(4-[perflurohexyl]phenyl)propionic acid as a white powder.

Provenance & Evidence