Hydrochloric Acid → HCID 15062349, compound

Participants

Reaction Steps

Ethyl 2-(4-[perfluorooctyl]phenyl)propionate (68 mg, 0.11 mmol) was dissolved in 5 mL of ethanol and 5 mL of 1N NaOH. The solution was heated to reflux for 1 hour, cooled to room temperature, poured into 30 mL of 1N HCl and extracted with three 10-mL portions of dichloromethane. Combination, drying (MgSO4), and concentration of the organic layers gave a residue which wa purified by PTLC (one 2 mm silica gel plate eluted with 15% methanol-85% dichloromethane) to give 61 mg (94% yield) of 2-(4-[perfluorooctyl]phenyl)propionic acid as a brown oil. The oil was recrystallized from dichloromethane to give brown crystals.

Provenance & Evidence