L-Phenylalanine → Aspartame

Participants

Reaction Steps

In a known process which does not use L-phenylalanine methyl ester, N-formyl-L-aspartic anhydride is subjected to a condensation reaction with L-phenylalanine in acetic acid and then the formyl group is removed in the presence of an aqueous hydrogen halide solution. The reaction product is subsequently esterified by treating with water, alcohol and the aqueous hydrogen halide solution, and α-L-aspartyl-L-phenylalanine methyl ester is isolated in the form of its hydrogen halide salt (U.S. Pat. No. 3,933,781).

Provenance & Evidence