反应详情

In 28.6 g of acetic acid, 14.3 g (0.1 mole) of N-formyl-L aspartic anhydride was suspended and 9.2 g (0.11 mole) of sodium acetate was added with stirring at 5°-10° C. Successively 21.6 g (0.1 mole) of L-phenylalanine methylester hydrochloride was added and the reaction was carried out for 5 hours with stirring at the same temperature. The reaction mixture was then concentrated and 57.2 g of water was added. Precipitated crystals were filtered, washed and dried. Crystals of N-formyl-α-L-aspartyl-L-phenylalanine methyl ester thus obtained were 30.6 g.

1. stirringwith stirring at the same temperature
2. concentrationThe reaction mixture was then concentrated
3. addition57.2 g of water was added
4. customPrecipitated crystals
5. filtrationwere filtered
6. washwashed
7. customdried