Ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate → 3,4-Dihydro-3-[2-[2-bromo-5-trifluoromethylphenylamino]-2-oxoethyl]-4-oxophthalazine-1-acetic acid ethyl ester

Participants

Reaction Steps

To a solution of ethyl 4-oxo-3H-phthalazin-1-ylacetate (3.36 g) and potassium t-butoxide (1.62 g) in dimethylformamide (15 ml) was slowly added a solution of 2'-bromo-5'-trifluoromethyl-2-chloroacetanilide (4.55 g) in dimethylformamide (15). After stirring the resulting solution overnight at room temperature, it was poured onto water (50 ml) and the resulting white precipitate was collected and air dried (yield 4.3 g; m.p. 160° C.).

Provenance & Evidence