Acetone → HCID 86747768, compound

HRID 1464259Notes

Reaction equation

HRID 1464259 reaction equation
Br[CH2:2][N:3]1[NH:12][C:11](=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].[N-:20]=[N+:21]=[N-:22].[Na+].CC(C)=O>[I-].[K+].O>[N:20]([CH2:2][N:3]1[NH:12][C:11](=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[N+:21]=[N-:22]

Participants

6

Reactant 3

HCID 180AcetoneHCID 33557Sodium AzideHCID 67793517HCID 67793517, compound

Product 1

HCID 86747768HCID 86747768, compoundYield 96.1%

Reagents, catalysts & solvents 2

HCID 4875Potassium IodideCatalystHCID 962WaterSolvent

Procedure

A mixture of ethyl 2-bromomethyl-4-oxo-3H-phthalazine-1-yl-acetate (2.0 g), sodium azide (0.4 g), acetone (20 ml), water (2 ml) and a catalytic amount of potassium iodide (10 mg) was stirred at room temperature for 4 hours. The mixture was concentrated under vacuum to remove the solvents and obtain the title product as a white solid (1.7 g).

Workup

  1. concentrationThe mixture was concentrated under vacuum
  2. customto remove the solvents

Sources & evidence

ORD record
ord-3364362973724d9c8e49a087cfed8ce6
Source dataset
uspto-grants-1994_04
Patent number
US05304557

Reaction notes

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