1,4-Dioxane → HCID 19087677, compound

HRID 1464275Notes

Reaction equation

HRID 1464275 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][NH:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12]([NH2:14])=[O:13])=[O:5])[CH3:2].[O:19]1CCOC[CH2:20]1>C(O)C>[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][N:9]1[C:10]2[C:11](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:12](=[O:13])[NH:14][C:20]1=[O:19])=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 13111329Ethyl 4-(2-carbamoylanilino)butanoate

Product 1

HCID 19087677HCID 19087677, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 2-(3-ethoxycarbonylpropylamino)benzamide (1.95 g) and N,N'-carbonyldiimidazole (2.52 g) in dioxane (20 ml) was heated to 150° C. After 30 minutes, the mixture was cooled below 80° C., and diluted with ethanol to give crude crystals. Collected crystals were recrystallized from ethanol to give 1-(3-ethoxycarbonylpropyl)-2,4(1H,3H)-quinazolinedione (1.53 g) as a crystal.

Workup

  1. temperaturethe mixture was cooled below 80° C.
  2. customto give crude crystals
  3. customCollected crystals
  4. customwere recrystallized from ethanol

Sources & evidence

ORD record
ord-5e8767fd3ea54d008eb69975981a3378
Source dataset
uspto-grants-1994_04
Patent number
US05304560

Reaction notes

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