Phosphorus tribromide → HCID 19087651, compound

Participants

Reaction Steps

A mixture of 2-[N-{4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl}-N-ethoxycarbonylamino]-6nitrobenzoic acid (680 mg) and phosphorus tribromide (0.7 ml) in methylene dichloride (30 ml) was refluxed for 3 hours. Excess of phosphorus tribromide was quenched with ethanol (2 ml) on an ice-bath. Then appeared crystalline materials were collected, and washed with ethanol to give 1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-5-nitro-1,2-dihydro-4H-3,1-benzoxazine-2,4-dione hydrobromide 414 mg).

Provenance & Evidence