Potassium Iodide → HCID 19087708, compound

Participants

Reaction Steps

A mixture of 1-(4-chlorobutyl)-2,4(1H,3H)-quinazolinedione (160 mg), N-(2-propoxyphenyl)piperazine hydrochloride (178 mg), potassium iodide (105 mg), and sodium carbonate (200 mg) in methyl isobutyl ketone (15 ml) was refluxed for 5 hours. After dilution with ethyl acetate, the reaction mixture was washed in turn with water and brine, dried over magnesium sulfate, and evaporated. The residue was chromatographed on silica gel (15 g) eluting with chloroform-methanol (50:1 V/V) to give 1-[4-{4-(2-propoxyphenyl)piperazin-1-yl}butyl]-2,4(1H,3H)-quinazolinedione (266 mg).

Provenance & Evidence