Triethylamine → HCID 19087731, compound

Participants

Reaction Steps

A mixture of 1-(4-methanesulfonyloxybutyl)-2,4(1H,3H)-quinazolinedione (312 mg), 4-phenyl-1,2,3,6-tetrahydropyridine (200 mg) and triethylamine (303 mg) was refluxed for 1.5 hours. The reaction mixture was poured into ethyl acetate-water, extracted with ethyl acetate. Combined organic extract was washed in turn with water and brine, dried over magnesium sulfate, and evaporated. The crude residue was washed with hot methanol to give 1-[4-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)butyl]-2,4(1H,3H)-quinazolinedione (114 mg) as a powder.

Provenance & Evidence