Diisopropyl Ether → 1-[4-{4-(2-Aminophenyl)piperazin-1-yl)butyl]-2,4(1H,3H)-quinazolinedione

Participants

Reaction Steps

To a solution of 1-[4-{4-(2-nitrophenyl)piperazin-1-yl}butyl]-2,4(1H,3H)-quinazolinedione (90 mg) in ethanol (8 ml) was added tin(II) chloride (159 mg) at 80° C. After stirring for 1 hour at the same temperature, the reaction mixture was quenched with ice and saturated aqueous sodium bicarbonate, and extracted with chloroform. The organic extract was washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and evaporated to give an amorphous. 1-[4-{4-(2-Aminophenyl)piperazin-1-yl)butyl]-2,4(1H,3H)-quinazolinedione (31 mg) was obtained by crystallization of the amorphous from diisopropyl ether.

Provenance & Evidence